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    • 专利摘要:
    Invention: as a salidi-uretic and diuretic in medicine, The essence of the invention: the product is 4-chloro-3-sulphamoylbenzoic acid of the general formula Rl H n IR-CO where I am, - H, C-C4-elki / 1 , C-C / alkyl-thio group, mercapto; Kg - H, RJ - H, trifluoromethyl, carboxy, alkoxycarbonyl, sulfamoyl. Reagent 1: Aminobenzimidazole derivative. Reagent 2: Carboxylic acid derivative. Reagent 3: alkali. Turning, if necessary, into salt. 2 tab. (L
    公开号:SU1736339A3
    申请号:SU884613207
    申请日:1988-12-30
    公开日:1992-05-23
    发明作者:Палоши Эндре；Корбонитш Деже；Молнар Эржебет；Свобода Ида；Харшинг Ласло；Шимон Дьердь；Вираг Шандор；Гергели Вера；Мармароши Каталин
    申请人:Хиноин Дьедьсер Еш Ведвесети Термекек Дьяра Рт (Инопредприятие)；
    IPC主号:
    专利说明:

    No longer in the hot water bath for 5 hours. After cooling, the mixture is filtered and the filtrate is evaporated under reduced pressure to give a gummy mass as a residue, which is mixed together with 1500 ml of water until it turns into a powder. this is filtered off with vacuum, washed with water and dried at P.O.C. 203 g (yield 94.7%) of 4-methoxycarbonyl-2-nitro-M- (4-chloro-3 - -sulfamoylbenzoyl) -phenylhydrazine with so pl. 144-147 ° C.
    Calculated,%: C 42.01; H 3.05, N 13.07, C1 8.27, S 7.48.
    C H ClNqOiS
    Found;%: C 41.7G. H 3.38; N 13, On; C1 8.01; S 7.86.
    C) 10 g of Rene nickel as a catalyst is added to a solution that contains 60 g of nitro compound,
    ethanol bath. The prepared solution is boiled for 1 h, then cooled and the pH is adjusted to 4-5 with 2N hydrochloric acid.
    0 The precipitate is filtered off with a vacuum and washed with water and dried at 80 ° C. As a result, G1, P-g (75% yield) of 1- (4-chloro-3-sulfamoylbenzoyl) amino-5-carboxybenzimidazole-25 -thion are obtained. in beige powder with
    m.p. 290-295 C (with decomposition). After purification according to example 1, the product is identical to the product according to example 1, Preparation of the starting product, A) 25.7 g, 4-tags, sicarbonyl 2- -nitro-M- (4-chloro-3 -sulfamoylbenzoyl) phenylhydrazine is mixed with 120 ml 2 n, hydroxide solution
    sodium, at 50 ° C for 4 hours. After cooling, the pH of the dark violet solution is adjusted to 5 by adding 2N. hydrochloric acid. The yellow precipitate is filtered with vacuum,
    0
    washed with water and dried at 8 ° C to obtain 23 g (yield: 92.5%) of 4-carboxy-2-nitro-M- (4-chloro-3 -sulfamoylbenzoyl) phenylhydrosine as a yellow powder; mp. WITH.
    Calculated,%: C 40.53) H 2.67, N 13.50, C1 8.50; S 7.70,
    C / 4H / f
    Found,%: C 40.23, H 2.88;
    N 13.76; ci 8, s 7.66.
    C) 4 g of 10% palladium on carbon as a catalyst was added to a suspension of 41.4 g of the nitro compound,. prepared according to method A of example 2, in 500 ml of 9b-ethanol. Then, the reaction mixture is heated with stirring to 60-70 ° C and 150 ml of 30% aqueous solution of sodium hypophosphate is added dropwise at a rate that avoids intensive foaming. After cooling, the mixture is filtered and the filter cake is stirred with
    1736339
    (94% yield) 1- (4-chloro-3-sulphamoylbenzoyl) -amino-5-methoxykerbo nylbenzimidazole-2-thione with m.p. 258-261 ° С (with decomposition) after its preliminary recrystallization from a mixture of dimethylformamide with water in a 1: 2 ratio.
    Example 4. 0.85 ml of the thiophos 10 gene is added dropwise to a solution which contains 4 g of 2-amino-4-methoxycarbonyl-N- (4-chloro-3f-sulfamoyl-benzoyl) -phenylhydrazine in 22 ml of 1 N . sodium hydroxide solution
    jj with simultaneous mixing and cooling with water. The mixture is stirred at room temperature for 4 hours, after which it is boiled under reflux for
    20 30 min. After cooling, the p value of the mixture is adjusted to 7 by the addition of normal sodium bicarbonate solution, stirred for 30 minutes, then the pH is adjusted to 5 to 30
    filtered off with vacuum, washed with water and dried at 80 ° C, obtaining in the form of a beige powder of 4.35 g (yield - 98.5) 1 (4; -chloro-3-sulfamoylbenzoyl) -amino-5-methoxycarbonylbenzimidazol-2 -Tion with a melting point of 258-261 ° С (with decomposition) after preliminary recrystallization from a mixture of dimethylformamide with water in a 1: 2 ratio.
    70 ml of 2 N, solution of the hydroxide oxide by pressure of acetic acid. Precipitate ri. The catalyst is filtered off and the pH of the filtrate is adjusted to 5 by the addition of 2N hydrochloric acid. The precipitate is filtered off with suction, washed with water and dried at 80 C. As a result, 32 g (83% yield) of 2-amino-4-carboxy-M- (4-chloro-3-sulfamoylbenzoyl) -phenylhydrazine are obtained. from m.p. 240-24 ° C (with decomposition),
    After recrystallization from a mixture of dimethylformamide with water in a 1: 2 ratio, the melting point of this product is 245-246 ° C (with decomposition),
    Calculated, $: C 43.70, and 3.40; -N 14.56; CJ. 9.2i; s 8.33.
    Q4 and "SSh058
    Found,%: C 3.83, H 3.40, N 14.21; ci 8.94; s 8,10.
    Example 3 A mixture containing 8 g of 2-amino-4-methoxycarbonyl-N- {4-chloro-3-sulfamoylbenzoyl) -phenylhydrazine and 3.2 g of potassium ethyl xanthate in 30 ml of pyridine are boiled under reflux. for 30 minutes, after which pyridine is evaporated under reduced pressure. After dissolving the residue in 40 ml of glacial acetic acid, the solution is poured into 160 ml of water. The precipitate is filtered off with a vacuum, washed with water and dried at. As a result, in the form of a pink powder, 8.2 g are obtained.
    35 1
    Example 5. 2.54 g of 4-chloro-3-sulphamoylbenzoyl chloride was added with stirring in small portions to a solution of 2.2 g of 1-amino-5-me
    40 toxicarbonylbenzimidazole-2-thione in 8 ml of dimethylformamide and 1.4 of triethylamine. The reaction mixture is left to stand overnight, then the pH is adjusted to 5 by the addition of uksu
    acid and diluted with a mixture of 100 water. The gummy resin released is destroyed to a powdery state, which is filtered off with vacuum, washed with water and dried at 80 ° C. The resulting crude product is boiled with 10 ml of glacial acetic acid for 30 minutes and then poured into 50. ml of water . Allocate sha with tar-like mass when you
    Sewing is destroyed to form a powder. The precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. As a result, 2.4 g are obtained in the form of a beige powder (you
    eight
    (94% yield) 1- (4-chloro-3-sulphamoylbenzoyl) -amino-5-methoxycarbonylbenzimidazole-2-thione with m.p. 258-261 ° С (with decomposition) after its preliminary recrystallization from a mixture of dimethylformamide with water in the ratio 1: 2.
    Example 4. 0.85 ml of thiophosgene is added dropwise to a solution that contains 4 g of 2-amino-4-methoxycarbonyl-N- (4-chloro-3f-sulfamoyl-benzoyl) -phenylhydrazine in 22 ml of 1 N . sodium hydroxide solution,
    j with simultaneous mixing and cooling with water. The mixture is stirred at room temperature for 4 hours, after which it is boiled under reflux for
    30 min. After cooling, the pH of the mixture is adjusted to 7 by adding normal sodium bicarbonate solution, stirred for 30 minutes, then the pH is adjusted to 5 to
    filtered off with vacuum, washed with water and dried at 80 ° C, obtaining as a beige powder 4.35 g (yield: 98.5) 1 (4; -chloro-3-sulfamoylbenzoyl) -amino-5-methoxycarbonylbenzimidazole 2-tione with m.pl., 258-261 ° С (with decomposition) after preliminary recrystallization from dimethylfor-amide mixture with water in the ratio 1: 2.
    Acetic acid release. Sediment
    one
    Example 5. 2.54 g of 4-chloro-3-sulphamoylbenzoyl chloride are added in small portions with stirring to a solution of 2.2 g of 1-amino-5-methoxycarbonylbenzimidazole-2-thione in 8 ml of dimethylformamide and 1.4 of triethylamine . The reaction mixture was left to stand overnight, then the pH was adjusted to 5 with acetic acid and the mixture was diluted with 100 ml of water. The resinous product that separated was destroyed in a powder and filtered off with suction, washed with water and dried at 80 ° C. The resulting crude product was boiled with 10 ml of glacial acetic acid for 30 minutes and then poured into 50. ml of water. The resinous mass that is separated out with stirring is destroyed to form a powder, the precipitate is filtered off with i vacuum, washed with water and dried at 80 ° C. As a result, 2.4 g are obtained in the form of a beige powder (you
    water solution o.
    C 47.55; n 4.73;
    a course of 54.5%) 1- (4-chloro-3-sulfamo-benzoyl) amino-5 methoxycarbonyl - benzimidazol-2-thione with m.p. 258-261 ° C (with decomposition) after preliminary recrystallization from a mixture of dimethylformamide with water in a 1: 2 ratio.
    Getting the original product.
    A) After boiling, 105.6 g of 4-labels of sicarbonyl-2-nitrophenylhydrazine with
    1 l of glacial acetic acid for 1 h. The clear orange-red solution is evaporated under reduced pressure. The residue is stirred in 1500 ml of water, the crystalline precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. 123 g (97% yield) of 4-methoxycarbonyl-2-nitro-A-acetylphenyl hydramine are obtained as yellow powdery crystals. mp, 182 185 ° С, and after recrystallization from ethanol its m, pl, 190-192VC
    Calculated,%: C, 433; H, 4.38; N 16.59.
    C "H" NS05
    Found,% N, 16.58.
    B) 107.7 g of the benzoic derivative obtained by method A of example 5 is refluxed in 425 ml of 1N. sodium hydroxide solution for 10 minutes, and then the solution is filtered to give a clear, dark red solution, which is acidified to pH 3-5 with acetic acid. The crystalline precipitate is filtered off
    with vacuum, washed with water and dried at 80 ° C. 98 g (yield 96.4%) of 4-carboxy-2-nitro-N-acetylphenylhydrazine are obtained as a yellow crystalline solid with m.p. 262-263 ° C. After recrystallization from a 50% aqueous solution of ethanol, the temperature is melting increase to 272-274 ° C (with decomposition),
    C) A solution of 116.3 g of the nitro compound obtained according to method B of example 5 in 490 ml of normal sodium bicarbonate solution is filtered. A clear solution is obtained, which is subjected to hydrogenation in the presence of 10 g of 10% palladium on carbon as a catalyst until the absorption of hydrogen ceases. After filtering off the catalyst, the filtrate is acidified to pH 4 by adding
    1736339 10
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    five
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    five
    five
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    5 N hydrochloric acid. The crystalline precipitate is filtered off with vacuum, washed with water and dried at 80 C. A 80.9 g (79.6% yield) 2 amino-4-carboxy-M- is obtained as a beige solid crystalline product. acetylphenylhydrazine m.p. 145-150 C (with decomposition). After recrystallization from absolute ethanol, the melting point was increased to 156-158 ° C (with decomposition),
    Calculated,%: C 51, B7 (H 5.30; N 20.09.
    C9 Il fN303
    Found,%: C 51, 31; H 5.49; N 19.79,
     D) 62.75 g of the amine compound, half prepared according to the procedure C of Example 5, is dissolved in a solution of 36 g of potassium hydroxide in 450 ml of absolute ethanol, and then 20.5 ml of carbon disulfide is added and the mixture is boiled under reflux with stirring within 5 hours. A yellow solid crystalline material is precipitated. 250 ml of hot water is added to the mixture, the resulting solution is clarified with activated carbon, filtered and about 200 ml of ethanol are distilled off from the filtrate under reduced pressure. 65 ml of acetic acid is added to the remaining part of the solution, the yellow crystalline precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. 46 g (61% yield) of acetypamino-5 carboxyl are obtained as a white crystalline solid. sibenzimidazole-2-t-ion with so pl. 334-338 ° С after preliminary recrystallization from a 50% aqueous solution of ethanol.
    Calculated,% t C 48.00 N 3.6G, N 16.72) S 12.76.
     N3Y3038g
    Found,%: C 48.70; H 3.50; N 16.70; s 12.74.
    E) 25.1 g of the benzimidazole derivative obtained by the procedure D of Example 5 is boiled with 100 ml of 2N hydrochloric acid with stirring for 6 hours. After cooling, the crystals are filtered off with vacuum, washed with water and dried at 80 ° C. in the form of a beige solid crystalline product of 20.5 g (yield 98%) 1-amino-5-carboxybenz11
    imidazole-2-tione with the city of pl. 301 - 304 ° С (with decomposition).
    Calculated, I: C 45.92; H 3.37; N 20, OP; S 15.30.
    . ° 2.S
    Found,%: C 45.40, H 3.34;
    N 19.92; S 15.70.
    F) A suspension containing 20.5 g of a carboxylic acid, prepared according to Method E of Example 5, in 250 ml of methanol is saturated with gaseous hydrogen chloride and then boiled under reflux with stirring for 30 minutes, hydrogen chloride is gradually introduced . After cooling, the crystals are filtered off with vacuum and added to the wet state to 80 ml of normal sodium bicarbonate solution with vigorous stirring. After stirring for 30 minutes, the crystalline precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. Thus, 19.9 g (yield 391) of 1-amino-5-methoxycarbonylbenzimidazol-2-thione with m.p. 239 C (with decomposition) after preliminary recrystallization from a mixture of dimethylformamide with water in a ratio of 2: 1. ;
    Calculated: C 48.42, K 4.06; N 18.82; S 14.36.
    C9H9MeOg.5
    Found,%: C 48.16; H 3.9V, N 18.50; S 14.61.
    Example 6 12.7 g of anhydrous sodium carbonate dissolved in. 200 ml of water, are added to a suspension of 44.6 g of 1-amino-5-methoxycarbonylbenzimidazole-2-thione in 400 ml of dioxane, then the solution is added dropwise to this mixture while stirring and cooling with water to 15-20 ° C. , which contains 68 g of 4-chloro-3 (N-dimethylaminomethylidene) -sulfamoylbenzoyl chloride, in 400 ml of dioxane. After the addition is complete, the reaction mixture is stirred at 20 ° C for 2 hours and then filtered to obtain a clear solution. The filtrate is diluted with 2 L of water, the crystalline precipitate is filtered off with vacuum, washed with water and dried, the 84.5 g of the resulting crude product is dissolved in a hot form with 1 L of water with vigorous stirring. After cooling
     vacuum with vacuum, washed with water and dry at 80
    ten
    3.85,
    , 59;
    15
    20
    736339 -12
    crystalline precipitate filtered
    C. Prepared as a white powder 74.4 g (75.5% yield) 1- / 4 - -chloro-3 - (N-dimethylaminomethylidene) -sulfamoylbenzoyl / -amino-4-methoxycarbonylbenzimidazol-2-thione with t .pl. 238-239 C- (with decomposition).
    Calculated,%: C 45.92, H N 14.10; C1 7.13, S 12.90. Cf H, SC1% 05S Found;%: 45.45; H 3
    N 13.95; ci 7, y; s 13.16.
    86.8 g of the compound obtained above are stirred in 500 ml of 2N. sodium hydroxide solution at 50 ° C for 8 hours, and then the solution is clarified with activated carbon, filtered and the pH of the filtrate is added to 6 by adding 2N hydrochloric acid while cooling and vigorous stirring. After adding 100 ml of ethanol, the precipitated precipitate is filtered off with vacuum, washed with water and dried at a temperature. 80 C to obtain bU, b g (yield 81.4%) of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-carboxybenzimidazole-2-thione with m.p., 285 290 ° С (c decomposition). After purification, by analogy with the procedure of Example 1, both substances are completely identical. Example 7, after adding
    35 3.66 g of M, M-di- (methoxycarbonyl) -methylisourea in a solution of 2.06 g of 2-amino-4-methoxycarbonyl- (4-chloro-3 -sulfamoylbenzoyl) -phenylhydrazine in 10 ml of dimethylformamide received
    The 40 solution is boiled for 3 hours and then evaporated under reduced pressure. The residue is dissolved in 10 ml of warm glacial acetic acid, clarified with activated carbon,
    4S is filtered and the filtrate is poured into 100 ml of water. The precipitated crystals are filtered off with
    25
    thirty
    vacuum, washed with water and dried at CO C. The result is 3.7 g (yield 50–87%) of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-methoxy carbonylbenzimidazolone, m.p. zheniem).
    210-216 C (from
    3.7 g of the benzimidazole derivative obtained as above is stirred in 37 ml of 2N sodium hydroxide solution at 60 ° C for 5 hours. Then the mixture is illuminated131
    poured with activated carbon, filtered and the filtrate acidified with 2N. hydrochloric acid. The crystalline precipitate is filtered off with vacuum, washed with water and dried at 60 ° C. Thus, 2.6 g (yield 721) of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-carcamide are obtained in the form of a beige solid crystalline product. boxibenzimidazolone with melting point after recrystallization from a 50% aqueous solution of ethanol: 3396 ° C. Calculated
    2.70;
    C 43.85; n N 13.64, S 7.8C.
    With “N„ С1М 063
    Found%: C 43.57 | H 2.86; N 13.58; S 7.42.
    Example 8. 11 g of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-labels of sicarbonylbenzimidazole-2-thione is dissolved in a solution prepared from 0.58 g of metallic sodium and 10 ml of methanol. After adding 1.56 ml of porous methyl, the solution is boiled under reflux for 3 hours, then the methanol is evaporated and the residue is triturated in water. The powdery crystals are filtered off with vacuum, washed with water and dried at 80 ° C. The result is 10.8 g (yield 95%) of 1- (4-chloro-3 -sulfamoylbenzoyl) -amino-5-labels of sicarbonyl-2-netylthiobenzimidazole m.p. 186-188 ° С (with decomposition).
    Calculated,%: C 44.88, H 3, N 12.32; ci 7.79, s 14.10.
    , 5ClNnOsSz
    Found,%: C Mi, 75, H 3.68; N 12.50; C1 7.60; S 13.91.
    Example 9. Yu g of an ester obtained by the method of example 8 is hydrolyzed using 50 m 2 n sodium hydroxide solution in a manner similar to example 1. Thus, 9 g (yield 941) of 1- (4-chloro-3 - sulfamoylbenzoyl) -amino-6-carboxy-2-methylthiobenzimidazole, which is recrystallized from 50% -nrg aqueous solution of ethanol. The result is a substance with 1.5 molecules of crystalline moisture and t, pl.
    214-222 С (with decomposition).
    Calculated,% i С 41, Оb; H 3.44;
    N 11.97; C1 7.57; S 13.07. C # H, 3C1H40581-1.5NgO Found;% C 41.00; H 3.35,
    N and 7g; ci 7, n; s 13.15.

    14
    339
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    Example 10. 6.6 g of 1- (4-chloro-3-sulfamoyl benzoyl) amino-5-methoxycarbonyl benzimidazole-2-thione are dissolved in a solution prepared from 0.35 g of metallic sodium and 60 ml of methanol. After adding 2 ml of benzoyl chloride, the reaction mixture was heated under reflux for 16 hours and then evaporated under reduced pressure. The residue is triturated in water, the solid is filtered off and subjected to chromatographic treatment in a column after drying, silica gel is used as a sorbent, and a mixture of benzene and acetone in a 2: 1 ratio is used as an eluent. Thus, in the form of a white powdered solid product, 5.37 g {yield 67.8%) 2-benzylthio-1- (4-chloro-3 -sulfamoylbenzoyl) amino-5-methoxycarbonylbenzimidazole, m.p. 111-118 C (with decomposition). The value of this product is 0.90, it is determined by thin layer chromatography (TLC) using chloroform-acetic acid-methanol system.
    Calculated,%: C 52.02 N Z.bG, N 10.55; C1 6.68, S 12.08.
     . Found,%: C 52.32, H 4.00;
    N 9.90; ci 6, oo; | s 12.00.
    Example 11 A suspension that contains 5.3 g of 2-benzylthio-1- - (4-chloro-3-sulfamoylbenzoyl) -amino-5-methoxycarbonylbenzimidazole in 30 ml of 2N sodium hydroxide solution is stirred for 4 at 50 ° C. Meanwhile, most of the starting material is dissolved. After filtering off the insoluble part, the filtrate is neutralized by adding 30 ml of 2N. hydrochloric acid. The white precipitate is filtered off with vacuum, washed with water and dried to obtain 4.9 g (94.8% yield) of 2-benzylthio-1- (4-chloro-3-sulfamoyl) -amino-5-carboxybenzimidazole with 0 tons, mp, 190-196 C (with decomposition).
    Calculated,%: C 51,10J H 3.31,
    N 10.84; ci 6.86; s 12.40.
     C1N405SZ
    Found,%: C 49.23; H 3.77; N 11, GO; C1 6.84; S PG40.
    Example 12. 3.85 ml of a 35% hydrogen peroxide solution is added dropwise while adding to the suspension
    151
    9 g of (4Т-chloro-3 -sulfamoylbenzoyl) -α-2-methylthio-5-methoxycarbonylbenzimidazole in 20 ml of glacial acetic acid. The reaction mixture is then stirred in hot water for 90 minutes. After cooling, the solid is filtered off with suction, washed with water and dried. Prepared as white powder, b, g (yield 65.7%) of 1- (4-chloro-3 -sulfamoyl-benzoyl) -amino-5-methoxycarbonyl-2-methyl-sulfonyl-benzimidazole, m.p. 25 -255 ° C (with decomposition) after recrystallization from a mixture of dimethylformamide with water in a 1: 1 ratio.
    Calculated,%: C 41.93, H 3.10; N 11.50; C1 7.28; S 13.17.
    CnH 5ClN404S2
    Found,%: C 42.01; H 3.15, N 11, C1 7.35; s 13.01.
    Example 13. (Suspension containing 5.4 g of 1- (4-chloro-3-sulfa-moylbenzoyl) -amino 5-methoxycarbonyl-2-methylsulfonylbenzimidazole in 30 ml of 2N sodium hydroxide solution is stirred at for C The result is a clear violet solution, which is clarified with activated carbon, filtered and the filtrate is acidified to pH 2 by the addition of 2N hydrochloric acid. The white precipitate is filtered off with vacuum, washed with water and dried. g (yield 85.7%) 5-carboxy-1- {4-chloro-3 -sulf moilbenzo- yl) -2--emino metilsulfonilbenzimida- ash m.p. 222-225 ° C (with decomposition), which does not change after recrystallization from a mixture of dimethylformamide with water in the ratio 3: 2.
    Calculated,%: C 40.64, H 2.77, N 11.85; ci 7.50; s 13.56.
    CfeH23ClN ,, 0-, Sa
    Found,%: C 40.07, H 3.01; N 12.02; ci 7.65; S 13.29.
    Example 14. 17.25 g of 4-chloro-3- (K-dimethylaminomethylidene) -sulphomoylbenzoyl chloride was added to a suspension of 11.45 g of 1-amino-5-methoxy-carbonyl-2-methylbenzimidazole in 25 ml of pyridine. Then the reaction mixture is heated to 60-70 ° C to obtain a yellow solution. The thick yellow mixture was left to stand overnight, then 200 ml of water was added. Having isolated from a yellow tar-like mass, it destroys36339
    sixteen
    with the formation of Pezhivoy powder after stirring for several minutes. The product is filtered off with suction, washed with water and dried to give 23.9 g (yield 90%) -chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl-amino-5-methoxycarbonyl-2-methylbenzimidazo-JQol with .pl. 240-245 ° C (with decomposition). After recrystallization from nitromethane, the melting point of the product is 2bO-2b3 ° C (with decomposition), Calculated,% C 50.26; H 4.22;
    N th, 65; ci 7.2; s 6.71.
    C20H20C1N505S
    Found,%: C 9.85, H, 31; N 15.12, ci 7.A4; s 6.52.
    Getting the original products.
    A) 235 ml of acetic anhydride is added to a suspension of 97.5 g of 2-amino-4-β-carboxy-H-acetylphenyl hydrazine in 50 ml of dichloromethane with simultaneous stirring. This mixture is stirred at room temperature in
    for 3 h, then the crystals are filtered off with vacuum, washed with chloromethane and dried at 60 ° C. (you 15
    20
    thirty
    35
    Thus, 101.2 g are obtained,. course 86.5%) of 2-acetylamino-4-carboxy-α-N-acetylphenylhydrazine with m.p., 238 ° C (with decomposition).
    Calculated,% C 52,58; H 5.2G, N 16.93.
    C4 H 3N30 / i
    Found,%: C 52.82; H 5.12;
    40
    N 17.20.
    B) 101.2 g of the acetyl derivative obtained in the example is boiled in 800 ml of acetic acid for 13 hours and then evaporated under reduced pressure. After stirring the residue in 800 ml of water, the crystalline precipitate is filtered off with vacuum, washed with water and the outlets - 45 is watered at 80 ° C. A 73.1% (yield: 78.5%) of 1-acetylamino-5-carboxy-2-methylbenzimidazole is obtained in the form of a white powdered solid with mp. 293-29 ° С (with decomposition).
    50
    55
    . Calculated,%: C 56.65, H, 75, N 18.02,
    C, fHMN303
    Found,%: C 56.7 G, H 4.62; N 17.89.
    C) 73.1 g of the benzimidazole derivative obtained according to the procedure B of Example 14 are boiled in 310 ml of 2N. hydrochloric acid for 5. A thus obtained transparent solution is clarified with activated carbon and filtered. After cooling, the crystalline, tallic precipitate is filtered under vacuum. It is washed with a small volume of water and dried at PO C. As a result, in the form of snow-white shiny plates (68.9 g (yield 96%) of 1-amino-5 carboxy- 2-methylbenzimidazol chloride with mp 287-288 C (with decomposition).
    Calculated,%: C, 47.48, H, 4.43; N 18.46; C1 15.17.
    CS H ClNjOA
    Found, I: C 47.85; H 4.83, N 18.15; C1 15.20.
    D) 68.1 g of the hydrochloride obtained by the method of example 14, Sus
    15
    filtered with vacuum, washed with water and dried. 26 g of 2-acetylamino-4-methoxycarbonyl-H- / 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl) -phenylhydrazine are obtained, m.p. 21B 220 ° C (with decomposition). 26 g of the product thus obtained are boiled in 200 ml of glacial acetic acid for 5 hours. The clear yellow solution is evaporated under reduced pressure and the residue is triturated in water. The precipitated crystals are filtered with vacuum, washed with water and dried. Thus, 24.5 g (98% yield based on the starting amino compound) of 1- / A - -chloro-3 - (N-dimethylaminomethylidene) are spun in 1 liter of methanol as a beige powder. Next, repeat the sulfamoylbenzoyl-amino-5-methoxyl steatte procedure F of Example 5, to obtain 48 g (yield 78%) of 1-amino-5-methoxy-carbonyl-2-methylbenzimidazole with m.p., 220-222 ° C.
    Calculated,% -. C 58.53; H 5.40; N 20.48.
    C0H "N302
    Found,%: C 58, s; H 5.38, N 20.25.
    E) To a suspension containing 14.5 g of 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoic acid in 50 ml of tenil chloride are added 2 drops of dimethylformamide. The reaction mixture is heated under reflux with stirring for 2 hours, then filtered to obtain a clear solution. The filtrate is evaporated under reduced pressure. The result is 12.7 g (yield 82%) of 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl chloride as a snow white solid with mp. 140 ° C. After recrystallization from benzene, the melting point is raised to 154-155 ° C,
    Calculated,%: C 38.84; H 3.26J N 9.06, C122.93; S 10.37.
    thirty
    carbonyl-2-methylbenzimidazole with so pl. 245-255 С (with decomposition). The melting point of the recrystallization from nitromethane can be increased.
    25 to 260-263 ° C. This product turns out to be identical to the product of Example 14.
    Preparation of raw materials, A) 17.75 g of crystalline sodium carbonate, dissolved in 330 ml of water, are added to a suspension of 70.76 g of 4-methoxycarbonyl-2-nitrophenylhydrazine in 670 ml of dioxane, 103.6 g of 4-chloro-3 - (N-dimethylaminomethylidene) -sulfamoyl benzoyl chloride, dissolved in 280 ml of dioxane, was added dropwise to the above mixture with stirring, resulting in a dark, transparent solution. The pH value of the reaction mixture is periodically adjusted, keeping it at about 7 periodic addition of normal sodium bicarbonate solution. After the addition is complete, the mixture is stirred for an additional 1 hour and then diluted with 1 l of water. The precipitate is filtered with vacuum, washed with water and dried at. Obtain 127.8 g (yield 78.8%) of 4-methoxycarboN
    Cf0H, 0Clj, N203S
    Found,%: C 38.28, H 3.07; °
    8.94; C123.14; S 10,58.
    Example 15. A mixture containing 25 g of 2-amino-4-methoxycarbonyl-N-4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl-J-phenylhydrazine in 80 ml of acetic anhydride is kept at room temperature in overnight and then mixed with 250 ml of water. Crystals
    0
    five
    filtered with vacuum, washed with water and dried. 26 g of 2-acetylamino-4-methoxycarbonyl-H- / 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl) -phenylhydrazine are obtained, m.p. 21B 220 ° C (with decomposition). 26 g of the product thus obtained are boiled in 200 ml of glacial acetic acid for 5 hours. The clear yellow solution is evaporated under reduced pressure and the residue is triturated in water. The precipitated crystals are filtered with vacuum, washed with water and dried. Thus, 24.5 g (98% yield based on the starting amino compound) of 1- / A - -chloro-3 - (N-dimethylaminomethylidene) sulfamoylbenzoyl-amino-5-methoxy-sulfamoylbenzoyl-amino-5- is obtained in the form of a beige powder. methoxy
    carbonyl-2-methylbenzimidazole with so pl. 245-255 С (with decomposition). The melting point of the recrystallization from nitromethane can be increased.
    to 260-263 ° C. This product turns out to be identical to the product of Example 14.
    Preparation of raw materials, A) 17.75 g of crystalline sodium carbonate, dissolved in 330 ml of water, are added to a suspension of 70.76 g of 4-methoxycarbonyl-2-nitrophenylhydrazine in 670 ml of dioxane, 103.6 g of 4-chloro-3 - (N-dimethylaminomethylidene) -sulfamoylbenzoyl chloride, dissolved in 280 ml of dioxane, was added dropwise to the above mixture with stirring, resulting in a dark, transparent solution. The pH value of the reaction mixture is periodically adjusted, keeping it at about 7 periodically by adding normal sodium bicarbonate solution. After the addition is completed, the mixture is stirred for an additional 1 hour and then diluted with 1 liter of water. The precipitate is filtered with vacuum, washed with water and dried at. It gives 127.8 g (yield 78.8%) of 4-methoxycarbonyl-2-nitro-4-chloro-3- (N-methydaminomethylidene) -sulfamoyl benzoyl 7-phenylhydrazine with m.p. 243-247PC. After recrystallization from nitromethane, the melting point is raised
    TO 255-256RS. t
    Calculated,%: C 44.68; H 3.75i N 14.47; C17.33, S 6.63. GeH1jClN50 S
    N is, h; ci 7.81.
    Sy HwClNjO $ S
    Found, I: C 7.80; H b, 25; N 15, C1. ,
    Example 16. 23.9 g of 1- /.) - -chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl-3-amino-5-methoxy-carbonyl-2-methylbenzimidazole is stirred in 150 ml of 2N. sodium hydroxide solution at 50 ° C until the ammonia formation process is terminated. During this period, a yellow solution formed. After cooling, the solution is acidified to pH 1 by the addition of 2N hydrochloric acid. The precipitate is filtered with vacuum, washed with water and dried. Prepared as a white powdery product of 1- (t-chloro-3-sulfamoyl-benzoyl) -amino-5-carboxy-2-methyl-benzimidazole with t, pl.293-296 ° C (with decomposition) after recrystallization from 50% aqueous solution of ethanol.
    191
    Found,%: With kkJQ; H 3.69; N 1.70; C1 7.53, S 6.79.
    C) Sg of 10% palladium on carbon as a catalyst is added to a slurry of 6l r nitro compounds prepared as described in Example A of Example 15 in 0 ml of 96% ethanol. The mixture is kept at 60-70 ° C and 250 ml of a 30% aqueous solution of sodium hypophosphite is added dropwise at the same temperature at such a rate to avoid intensive foam formation. After completion of the addition operation, the mixture is stirred for an additional 30 minutes at 60-70 ° C. After cooling, the mixture is filtered, the solid product is mixed with 250 ml of dioxane, filtered, and the filtrate is evaporated under reduced pressure. After rubbing the residue in 200 ml of a 50% aqueous solution of ethanol, the crystals are filtered with vacuum, washed with 50% ethanol and dried at 80 ° C. Thus, 40 g (yield 68%) of 2-amino - methoxycarbonyl-N- / -chloro-3- (N-dimethylaminomethyl) -sulfamoylbenzoyl-phenylhydrazine with mp, 219-220 ° C (with decomposition).
    Calculated,%: C 47.63; H 4, And,

    Calculated,%: C 7.00; H 3.20, N 13.71; C1 8.671 S 7.85.
    C IlfjClf OsS
    2P
    0
    five
    five
    0
    Found C, 45.80; H 3.71; N 13.93, C1 8.80; S 7,7,
    Example 17. The procedure of Example k is repeated except that in this case 10.63 g of 1-amino-5 methoxycarbonylbenzimidazole are used as the starting compound. As a result, 21.1 g (82% yield) of 1-chloro-3 - (M-methyl-amino-ethylidene) -sulfamoyl benzoyl / - -amino-5-methoxycarbonyl benzimidazole are obtained in the form of a pale yellow powder. 2 9-252 С (with decomposition).
    Calculated,%: C 9.19, H 3.9 O N 15.10, S 6.91.
    C / 9H, f niN $ S
    Found,%: C 9, b2, H, 36; N 15.30; S 6.68.
    Getting the original products.
    A) 2.5 g of 10% palladium on carbon as a catalyst was added to a solution of 25.3 g of A-methoxycarbonyl-2-nitro-N-acetylphenylhydrazine in 380 ml of methoxyethanol and the mixture was hydrogenated in a shaker. until the termination of the hydrogen uptake process. After filtering off the catalyst, the filtrate is evaporated under reduced pressure and the residue is mixed with 100 ml.
     water, the precipitated crystals are filtered with vacuum, washed with water and dried at 80 ° C. Thus, 19.1 g (yield 85.6%) of 2-amino-methoxycarbonyl-N-acetylphenylhydrazine are obtained in the form of a beige crystalline 5 solid. from m.p. 175-17 C. After recrystallization from methanol, the melting point 0 is increased to 180-182 C.
    Calculated,%: C, 53.80; H, 5.87; N 18.82.
    C H13% 0,
    Found,%: C 53.17; H 5.9, 5 N 18.93.
    B) 22.3 g of the phenylhydrazine derivative obtained by the method are heated under reflux.
    And example 17, in 150 ml of anhydrous mu0
    0
    for 5 hours, a clear purple solution is evaporated under reduced pressure. As a result of pouring 250 ml of water into the residual resinous mass, a solution is obtained from which white crystals soon begin to precipitate. After soaking for several hours, the crystals are filtered off with ba21.
    cuum washed with water and dried 80 ° C. Received as white cree
    Tall solid 17.2 (76% yield) 1-acetylamino-5-methoxy-carbonyl-benzimidazole with m.p. 210- (with decomposition).
    Calculated,%: C 56.65, H 4.75i N 18.02. ,
    S „N„ Y30E
    Found%: C 5b, 55 | H 4.67; N 18.28.
    C) 32.5 g of the benzimidazole derivative obtained by the procedure B of Example 17 is boiled in 140 ml of 2N. hydrochloric acid for 5 hours. After the solution is clarified with activated carbon, filtered and cooled, the precipitated crystals are filtered off with vacuum, washed with a small amount of water and dried at 80 ° C. Thus, in the form of a snow white crystalline solid, 23 2 g (yield 78%) of 1-amino-5 carboxybenzimidazole hydrochloride with m.p., 325-330 ° H ..
    Calculated,%: C, 44.98; H 3.77; N 19.67, C1 16.60.
    CgH6ClN3Oz
    Found,%: C 44.49, H 3.80; N 19.68, C1 16.52.
    D) 26 g of the benzimidazole derivative obtained by the procedure C of example 17 is used to react with 270 ml of methanol containing hydrogen chloride, similarly to method F of example 5. For the hydrochloride thus decomposed, 220 ml of normal sodium bicarbonate solution are used. The result is 1-9,3 g (yield 83%) of 1-amino-5-methoxycarbonylbenzimidazole with so pl. 194-195 ° C.
    Calculated,%: C 56.54 H 4.75, N 21.98.
    C9HSN302
    Found,%: C 56.95, H 4.63; N 21.62.
    Example 18 28.7 g of 2-amino-4-methoxycarbonyl-K-4-chloro-3 - (R- -dimethylaminomethylidene) -sulfamoyl-benzoyl-phenylhydrazine are boiled in 200 ml of anhydrous formic acid for 6 hours. After evaporation of the solution under reduced pressure, the residue is triturated in water, the separated crystals are filtered off with vacuum, washed with water and dried. It is obtained in the form of a yellowish-beige powder.
    22
    ka
    g

    19 g (64% yield) 1- / V-chloro-3
    - (N-dimethylaminomethylidene) -sulfamoylbenzoyl | -amino-5-methoxycarbonyl5 benzimidazole, m.p. 240-253dC (with decomposition) In all aspects, this product turned out to be identical to the product of example 17.
    Example 19. The method of Example 16 is carried out with the exception that 6.5 g of 1- / 4-chloro-3 - (M: -dimethylaminomethylidene) -sulfamoylbenzoyl. 7-amino is used as starting materials in this case. -5-me15 toxicarbonylbenzimidazole and tO ml - 2 n. solution of sodium hydroxide solution. Thus, after recrystallization from a 50% aqueous solution of ethanol, 5.1 g (yield 921) 120 - (-chloro-3-sulfamoylbenzoyl) -a, mino-5-carboxybenzimidazole p. pl, 290-291 ° C (with decomposition) ,.
    Calculated,%: C 5.63, H 2.81; N 14.19; C1 8.98, S 8.12,
    25 CiSKu C1N, .05S
    Found,%: C 5.27; H 2.79; N 13.85; C1 8.93; S 7.71.
    Example 20. The procedure of Example 1 is repeated, except
    3Q. In this case, 2.32 g of 2-amino-4-cyano-M- (4-chloro-3-sulphamoylbenzoyl) disulfide, 1.07 g of potassium hydroxide and 4.5 ml are used as starting materials. absolute ethanol. Reactionary
    35 the mixture is acidified by the addition of 2k ml of acetic acid. Thus, 2.32 g (yield 97%) of crude product is obtained, which is purified by chromatography on a column of silica gel using a mixture of benzene and acetone in the ratio 1: 1 as eluent. Thus, T-β-chloro-3-sulfamoylbenzoyl) -amino-5-cyanobenzimidazole-2- -ion is obtained with mp, 315 ° C,
    Calculated,% g C 44,16; H 2.47; N 17.17; ci 8.69; s 15.72. C HfoCltM S
    Found,%: C 44.40; n 2.67; N 16.94, ci 8.96; s 15.33.
    Preparation of starting materials, A) Repeat procedure B of Example 1, using as starting material 5 materials 8.1 g of 4-cyano-2-nitrophenylhydrazine, 114 ml of dioxane, 46 ml of an aqueous solution of 2.4 g of crystalline sodium carbonate and 11.6 g of 4-chloro-3-sulphamoylbenzoyl chloride, solution 40
    45
    50
    231736339
    renalized in 53 ml of dioxane. After evaporation of the reaction mixture, the residue
    mix thoroughly with water, the precipitated yellow precipitate is filtered with vacuum, washed with water and dried at 80 ° C. Thus, after recrystallization from acetic acid, 3.75 G are obtained ((yield 65%) 2-4-cyano-2-nitro-M - (4-hpor-3-sulfa-moylbenzoyl) -phenylhydrazine with mp 292-295 ° С (with decomposition).
    Calculated,%: C 40.63; H 2.92; N 16.92, C1 8.57, S 7.78.
    CHHtoClN505S 0.5CH3COOH
    Found,%: C 40, On; H 2.52; N 16.85; C1 8.23; S 7.65,
    C) 1 g of Rene nickel as a catalyst is added to 8.54 g of the nitro compound obtained according to method A of example 20, dissolved in 500 ml of methoxyethanol, and then the mixture is subjected to hydrogenation under atmospheric pressure at room temperature. until the absorption of hydrogen ceases. After filtering off the catalyst and evaporation of the filtrate under reduced pressure, the residue is triturated in water, the precipitated white crystals of the precipitate are filtered with vacuum, washed with water and dried at 80 ° C. Thus, 6.62 g (yield 80%) of 2-amino-4- cyano- (4-chloro 3g -sulfamoylbenzoyl) phenylhydrazine with m.p. 205 C (with decomposition),
    Calculated,%: C 45.96; H 3.31; N 19.15, C1 9.69) S 8.77.
    C1EN4a ClNs-03S
    Found,%: C 46.06; H 3.28, N 19.21; C1 9.81; s 8.80.
    Example 21 The procedure of Example 1 is repeated using 2.9 g of 2-amino-4-benzyl N- (4-chloro-3-sulfamoylbenzoyl) phenylhydrazine, 10 ml of methanol, 2.8 ml of carbon disulfide and 1.2 g of potassium hydroxide dissolved in 4.5 ml of absolutized ethanol as starting materials. 24 ml of acetic acid are added to acidify the reaction mixture. After recrystallization of the crude product in the form of a wet filter cake from 96% ethanol, 1.7 g (57% yield) of 5-benzoyl 1- (4-chloro-3-sulfamoyl-benzoyl) -amine-benobimimidazole-2-thione with m.p. . 233 C (with decomposition),
    24
    Calculated,%: C, 51.75; H, 3.11; N, 11.51; ci 7.28; s 13.17. CiiHi ClNi, Oi, S Found,%: C 51.30; H 3.74;
    N p, 39; ci 7.4; s 13.50.
    Getting the original products.
    A) 20 ml of hydrazine hydrate are added to a suspension of 52.33 g of 4-chloro-3-nitrobenzo-Lenone in 200 ml of absolute ethanol with stirring. The reaction mixture is stirred at room temperature for 75 minutes and then gently heated.
    5 until boiling point. After completion of the vigorous reaction, the mixture is boiled under reflux for an additional 1 hour. After cooling, the crystals are filtered off with vacuum, washed thoroughly with water and dried at 80 ° C. Thus, 38.62 g are obtained as orange-red crystals (yield 75 %) 4-benzoyl-2-nitrophenylhydrazine with mp,
    5 163-164 „С.
    Calculated,%: C 60.89, H 4.31; N 16.33.
    C, 3H "N / b
    0 Found: C 60.60, H 4.15, N 16.40.
    B) Method B of Example 1 is repeated using 28 g of 4-benzoyl-2-nitrophenylhydrazine, 272 ml of dioxane, 5.8 g of anhydrous sodium carbonate dissolved in 217 ml of dioxane as starting materials. As a result, after recrystallization
    29.1 g (yield 61%) of 4-benzoyl-2 nitro-M- (4-chloro-3-sulfamoylbenzoyl) -phenylhydrazine with mp, 148 C are obtained from methanol.
    Calculated,%: C 50.58; H 3.18; N 11.80; C1 7.47; S 6.75.
    CZOHUC1N406S
    Found: C 49.59, H 3.15; N p, 46; ci 7.71; s 6.46.
    C) Method B of Example 20 was repeated, using as starting materials 23.7 g of the nitro compound prepared by Method B of Example 21 and 500 ml of methanol. The result is 19.7 g (yield 88.5%) of 2-amino-4-benzoyl-M- (4-chloro-3-sulfamoyl-benzoyl) -phenylhydrazine, m.p.
    162 C (with decomposition).
    Calculated,%: C, 53.99; H 3.85; N 12.591 C1 7.97, S 7.21.
    SgoN
    five
    0
    five
    0
    Found,% C 53, BO; n 3.94; N 12.87, C1 7.7G, S 7.43.
    Example 22. The procedure of Example 16 is repeated using 6.2 g of 1- / h -chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl} -aminobenzimidazole and AO ml 2N as the starting materials. sodium hydroxide solution. As a result, after recrystallization from 96% ethanol, 6 g (yield: 87.6%) of 1- (4-chloro-3-sulfamoyl-benzoyl) -α-aminobenzimidazole are obtained, m.p. (with decomposition),
    Calculated,% C 47.93; H 3.16; N 15.97; C1 10.11; S 9, and.
    WITH
    Found,%: C 47.50; H 3.08; N 15.70; C1 9.95; S 8.96. .
    Getting the original product.
    The procedure of Example 14 is repeated using 4 g of 1-aminobenzimidazole 7 ml of pyridine and 9.3 g of 4-chloro-3 (M-dimethylaminomethyl phenesulfamoyl benzoyl chloride) as starting materials. As a result, after recrystallization from nitromethane, 11.1 g (yield 91%) of 1- / 4-chloro-3- (N-dimethylaminomethylidene) -sulf moylbenzoyl 7-aminobenzimidazole are melted with mp. 258-2b1 ° C.
    Calculated,%: C 50.30, H 3.97; N 17.26; C1 8, S 7.90,
    Cl Hf6Cl% 03S
    Found,%: C 50.13, H 4.01;
    N 17.27; ci 8.90; s 8.03.
    p 23. Repeat method- 16 using
    Take an example
    5.1 g of 1- / 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl / -amino-2-methylbenzimidazole and 30 ml of 2 N as the starting materials were used. sodium hydroxide solution. As a result, after recrystallization from a mixture of dimethylformamide with water in a 1: 1 ratio, 3.7 g (yield 87%) of 1- (4-chloro-3-sulfamoyl-benzoyl) -α-amino-2-methylbenzimidazole are obtained with m. PL, 300 C (with decomposition)
    Calculated,%: C 49.38; n 3,591 N 15.36; C1 9.72; s 8.79. , 3C1N403S
    Found,%: C 49.18; n 3.56, N 15.20, C1 9.72; S 8.98.
    Getting the source material.
    0
    five
    five
    0
    five
    The procedure of Example 14 is repeated using 4.1 g of 1-amino-2-methylbenzimidazole, 15 ml of pyridine and 9.3 g of 4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl chloride. As a result, after recrystallization from a 96% aqueous solution of ethanol, 10.2 g (yield 77.6%) of 1 - // - - chloro-3 - (N-dimethylaminomethylidene) - -sulfamoylbenzoyl 7-mono-2-methylSenzimidazolhydrate are obtained. with t. pl. 166 C (with decomposition). After recrystallization from acetonitrile, the melting point reached 232-235RS.
    Calculated,%: C 49.36, H 4.60, N 15.991 Cl, 8.10; S 7.01.
    C0 H 6C1% Oz5
    Found,%: C 49.25, H 4.61;
    0 N 15.72; ci 8, y; s 7.10.
    Example 24 Repeat the procedure of Example 16 using 2.4 g of 1- - 4-chloro-3 - (N-dimethylaminomethyl-ideas) -sulfamoylbenzoyl3-amino-5 -sulfamyloenzimidazol-2-thion and 12 ml as starting materials. 2 n. sodium hydroxide solution solution. As a result, after thoroughly boiling in ethanol, 1.64 g (76% yield) of 1- (4-chloro-3-sulfamoyl benzoyl) amino-5 sulfonyl benzimidazole-2-thione with m.p. . (with decomposition),
    Calculated,%: C 36.40; H 2.62;
    15.16; ci 7.68; s 20.82.
    C-uH ClNyOs-Sa
    Found,%: C 36.31; H 2.45;
    15.66; ci 7.36; s 20.80.
    Getting the original products.
    A) 20 ml of hydrazine hydrate is added to a suspension of 47.33 g of 4-chloro-3-nitrobenzenesulfonamide in 20 ml of absolute ethanol. The mixture is boiled with stirring for 30 minutes and then cooled. The crystals are filtered with vacuum and washed thoroughly with water. 43.38 g (yield 93.4%) of 2-nitro-4-sulphamoylphenylhydrazine are obtained with a mp. 217-218 C (with decomposition).
    n 3.47;
    0
    five
    0
    326 ° С
    N
    N
    Calculated,%: C 31.0 N 24.13; S 13.81.
    SbNgY40 5
    Found,%: C, 31.50; H 3.48 N 24.37; S 13.57.
    C) Repeat procedure C of example 1 using 65.7 g of a nitro compound prepared according to method A of example 24, 700 ml of dioxane, 15 g of anhydrous sodium carbonate, dissolved
    271
    in 280 ml of water, and 87.5 g of h-chloro-3- (m-dimethylaminomethylidene) -sulfimoylbenzoyl chloride, dissolved in 5 O of dioxane. After evaporation of the reaction mixture under reduced pressure, the residue is thoroughly mixed with water, the solid product is filtered under vacuum and the wet filter cake is boiled in 600 ml of methanol. After filtration and drying, 121.5 g (yield 85%) of 2-nitro-4-sulf moyl-N- / h-chloro-3- (M-dimethylaminomethylidene) -sulfamoyl benzene-phenyl hydrazine with m.p. 248 C ( with decomposition) After recrystallization from glacial acetic acid, the melting point of the product is 252 ° C (with decomposition) Calculated,%: C 38.06; H 3.39;
    N 16.6ft; ci 7.02; s 12.70.
    C16Ep C1N60, S2
    Found,%: C 38.10; H 3.42;
    N 16.59; ci 7.00; s 12.68.
    C) Repeat procedure C of example 15 using as starting materials 5 g of the nitro compound obtained according to method B of example 2h, 60 ml of absolute ethanol, 0.5 g of 10% palladium on carbon as catalyst and 30 ml of 30% A sodium hydrochloride solution of sodium hyposulfite is obtained. Thus, 2 g (yield 88%) of 2-amino-4-sulfamoyl-H- - 4-chloro-3 (s-dimethylaminomethyl-den) sulfamoylbenzoyl-phenylhydrazide are obtained. on c. 152 C (with decomposition).

    D) The procedure of example 3 is repeated using as starting materials 4.75 g of the phenylhydrazine derivative obtained according to the method C of example 24t 20 ml of pyridine and 1.6 g of potassium ethylxanthanoate. Thus, 3.2 g (yield 62%) of 1- / 4-chloro-3 - (M-dimethylaminomethylidene) -sulfonylbenzimidazole -2-thio sulfide are obtained with a m.p. 12h C (with decomposition).
    Example 25. The procedure of Example 3 is repeated using as starting materials 6.3 g of 2-amino-4-methylsulfonyl-M (h-chloro-3-sulfamoylbenzoyl) phenylhydrazine, 35 ml of pyridine and 2, h of ethyl xanthate Kali. As a result, after recrystallization from a 50% aqueous solution, 5 g (yield 73%) of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-methylsulfonylbeni imidazol-2 thio on t. 298-3006С
    0
    five
    339
    i
    28
    Calculated, X: C 39.08; H 2.82; N 12.16, C1 7.69; S 20.87.
    Гtf Well C1N405S,
    Found, I: C 38.90) H 2.70; N 12.12; C1 7.98; S 20.60.
    Getting the original products.
    A) Repeat procedure A of Example 24 using 12.5 g of 4-methylsulfonyl-2-nitrochlorobenzene, 50 ml of absolute ethanol and 5.3 ml of hydrazine hydrate. As a result, 11 g (yield 32%) of h-methylsulfonyl-2-nitrophenylhydrazine with m.p. 188-190 ° C.
    Calculated,%: C 36.36; H 3.92; N 18.17; s 13.87. S7N zN3STs5
    20
    N
    25
    thirty
    five
    0
    N
    five
    0
    Found%: JC 36.23J H 3.36; 18.17, S 13.97.
    C) Repeat procedure B of example 1 using as starting materials 11 g of the phenylhydrazine derivative prepared according to method A of example 25, 120 ml of dioxane 2.5 g of anhydrous sodium carbonate dissolved in 47 ml of water, and 12 g h- chloro-3-sulfamoylbenzoyl chloride, dissolved in 95 ml of dioxane. Thus, after recrystallization from acetic acid, 19.5 g (yield; 9 h%) of h-methylsulfonyl-2-HHTpo-N- (h-chloro-3-sulphamoylbenzoyl) phenylhydrazine with m.p. 279 C (with decomposition).
    Calculated,%: C 35.73, H 3.00; 12.82, C1 8.11; S 1h, 67. C, 3% C1M40., 5g Found,%: C 35.75; H 2.90; N 12, che; C1 7.91; s 1h, 2h.
    C) Method C of Example 1 is repeated using 1 h, 8 g of the nitro compound obtained according to Method B of Example 25, 250 ml of methoxyethanol and 2 g of Rene nickel as a catalyst. As a result, after recrystallization from ethanol, 1 h is obtained, 1 g (yield 99%) 2-amino-h-methylsulphonyl- -N- (4-chloro-3 -sulfamoylbenzoyl) phenylhydrazine with m.p. 200 C (with decomposition),
    Calculated,%: S CHO, 1h; H 3.61; N 13.38; ci 8.46; N 15.31. C N "ClN4Oj-Sz
    Found,%: С чО, 5Т, H 3.77, N 13.65; C1 8.8z; S 15.43.
    Example 26. The procedure of Example 16 is repeated using
    29
    The starting materials used were 1- / V- -chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl7 amino-5-trifluoromethylbenzimidazole and 80 ml of 2N. solution of hydrate oxide nchtri. After recrystallization of the crude product and a mixture of benzene and acetone in a 1: 1 ratio, 1 g is obtained (yield 77.7% of 1- (4-chloro-3-sulfamoylbenzoyl) -amino 5 trifluoromethylbenzimidazole with mp. 164 C,
    Calculated,%: C 43.01; H 2.41; N 13.3Ј; S Cl 8.47.
    C / 5H, 0 ClFiN OiS
    Found%: C 43.82 | H 2.78; N 13.56; S C1 8,11.
    Getting the raw materials.
    A) 6 g of 2-nitro-4-trifluoromethylphenylhydrazine is maintained at an elevated temperature in 200 ml of 85% formic acid in a water bath
    within 90 min. After cooling, the yellow solution is poured into 250 ml of water. The precipitated crystals are filtered off with suction, washed with water and dried at 80 ° C. As a result, 70 g (yield 98%) of 2-nitro-4-trift ormethyl-M-formylphenylhydrazine with mp. 152-153 C.
    Calculated, o: C, 38.56; H 2, A3; N 16.86.
    CSH6F3N303
    Found,%: C, 38.38; H, 2.48; N, 16.98.
    B) 6 g of 10% palladium on carbon as a catalyst is added
    into a solution of 65.45 g of a nitro compound obtained according to the procedure A of Example 26 in 780 ml of absolute ethanol, and then the mixture is subjected to hydrogenation at room temperature until the process of hydrogen absorption ceases. After filtering off the catalyst, the filtrate is evaporated. 55.8 g of 2-amino-4-trifluoromethyl -N-formylphenylhydrazine are obtained with m, mp. 121-122 C.
    one
    Calculated,%: C 43.84; H 3,6Ј; N 19.18.
    CgHgF3N30.
    Found,%: C 43.25; H 3.94,
    N 19.19,
    C) After boiling 44 g of the phenylhydrazine derivative obtained by the procedure B of Example 26 in 200 ml of 85% formic acid for 5 hours, the red obtained
    1736339
    thirty
    the solution is evaporated under reduced pressure. After rubbing the residue in 200 ml of water, the crystalline precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. As a result, after recrystallization from a mixture of acetone and water in a ratio of 1: 2, 40.8 g are obtained (yield 88.7%) 1 -formylamino 5-trifluoromethyl-benzimidazole with m. pl. 209-210 ° С. Calculated,% -. C 47.17; H 2.64; N 18.34.
    C9H6F3N30
    5 Found,%: C 47.69; H 2.59; N 18,51.
    D) After boiling 15.11 g of the benzimidazole derivative obtained by the procedure C of Example 26 in 68 ml of 2N hydrochloric acid for 5 hours, the resulting solution is made alkaline by the addition of 2N. sodium hydroxide solution. The crystalline precipitate is filtered off with 5 vacuum, washed with water and dried at 80 ° C to obtain 11.7 g (yield, BB%) of 1.-amino-5-triftomethylbenzimidazole with m.p. 140-142PC.
    Calculated,% C 47.76; H 3.00, 0 N 20.89.
    C8H6F3N5
    Found,%: C 47.82; H 2.94; N 20.64.
    five
    0
    E) Repeat the procedure of Example 14 using as starting materials 8.69 g of the benzimidazole derivative obtained in Example 26, 10 ml of pyridine and 13.35 g of 4-chloro-3- (N-dimethylaminomethylidene) sulphamoylbenzoyl chloride . Thus, after recrystallization from methanol, 20.27 g (yield 100 #) of 1- (V-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl 7-amino 5 trifluoromethylbenzimidazole with mp 266-270 0 .
    Calculated% C 45.62; H 3.19, N 14.78; S 6.77.
    C, g% S1Gs% Oz
    Found: C, 45.50; H, 3.94; N, 14.35; S, 6.98.
    Example 27. The procedure of Example 16 was repeated using raw materials of 7.4 g of 1-4-chloro-3- (N-dimethylaminomethylidene) -sulfamoylbenzoyl amino-2-methyl-5 trifluoromethylbenzimidazole and 20 ml. 2 n. sodium hydroxide solution. As a result, after a re-draw
    talization from a mixture of benzene and acetone in a 1: 1 ratio gives 5.3 (yield 80.7%) of 1- (4-chloro-3-sulfamo-ylbenzoyl) -amino-2-methyl-5 trifluoromethylbenzimidazole with m, pl. 193 -.
    Calculated,%: C 44.4; H 2.8oJ N 12.95; C1 8.19.
    C, $ HyClF3N /, 03
    Found,%: C 44.92J H 2.64, N 13.13; C1 8.36.
    Getting the original products.
    A) After boiling 23.3 g of 2-amino-4-trifluoromethyl-M-acetylphenyl hydrazine in 120 ml of acetic acid and 20 ml of acetic anhydride for 6 h, the resulting orange-red solution is evaporated under reduced pressure.
    and the residue is triturated in water. The crystals that have separated out are filtered off with vacuum, washed with water and dried.
    at 80 ° C. As a result, after recrystallization from acetone, 23.2 g (yield 90%) of 1-acetylamino-2- -methyl-5-trifluoromethylbenzimidazole with mp. 214-21b ° C.
    Calculated,%: C, 51.36; H, 3.92; N 16.34.
    С // Н, 0 „
    Found,%: C 51.43, H 3.98; N 16.38.
    B) After boiling 71.14 g of the benzimidazole derivative obtained according to the procedure A of Example 27 in 300 ml of 2N hydrochloric acid for 5 hours, the yellow hot solution is clarified with activated carbon and filtered. The filtrate is neutralized to pH 6 by the addition of 10 n. sodium hydroxide solution. The snow-white crystalline precipitate is filtered with vacuum, washed thoroughly with water and dried at 8O C. As a result, 53.2 g (yield, 89.5%) of 1-amino-2-methyl-5 trifluoromethylbenzimidazole with m, pl. 190 - 192 ° C,
    Calculated,% C 50.23; H 3.75, N 19.23.
    SVVDKE
    Found,%: C 50.35, H 3.97, N 19.63.
    C) Repeat the procedure of example 14 using as starting materials 18.02 g of the benzimidazole derivative prepared according to the method B of example 27, 25 ml of pyridine and 25.9 g of 4-chloro-3 - (- dimethylamino
    five
    methylidene) sulfamoylbenzoyl chloride. The result is 34.4 g (84% yield) of 1- (4-chloro-3 - (N-dimethylamino-methylidene) -sulfamoylbenzoyl) -amino-2-methyl-5-trifluoromethylbenzimidazole, m.p. 300 ° C.
    Example 28, Repeat the procedure of Example 16 using 11.33 g as starting materials.
     -chloro-3- (N-dimethylamino-methyl-idene) -sulfamoylbenzoyl7 amino-5-tri-j fluoromethylbenzimidazole-2-thione and 50 ml 2 n. sodium hydroxide solution. Thus, after recrystallization from a 50% aqueous solution of ethanol, 7.92 g (yield: 77.7%) of 0 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5-trifluoromethylbenzimidazol-2-thione with m.p. 282-2 3 C (with decomposition).
    Calculated,%: C 39.96, H 2.24; N 12.43, C1 7.86.
    C / sH / oFjCl O Sz
    Found,%: C 39.09; H 2.12, N 12.20; C1 7.11.
    Getting the original products.
    A) The procedure of Example 14 was repeated using 8.84 g of 2-nitro-4-trifluoromethylphenylhydrazine, 50 ml of pyridine and 12.36 g of 4-chloro-3 (N-dimethylamino-methylidene) sulfamoyl benzoyl chloride as starting materials. As a result, after recrystallization from acetic acid, 17 g (yield 86%) of 2-nitro-4-trifluoromethyl- -chloro-3- (N-dimethylaminomethyl-) -sulAamoylbenzoid-phenylhydrazine with ToPL is obtained. (Ј Decomposition
    Calculated,%: C 41.34; H 3.06, N 14.19.
    C, H | y ClFaN O
    Found,%. C 41.23, H 3.36, N 14.09.
    B) Method B of Example 2 was repeated using 17 g of the nitro compound obtained by Method A of Example 28, 1, palladium on carbon as a catalyst, 100 ml of 96% ethanol and 60 ml of a 30% aqueous solution of hypophosphite as starting materials. on three . Thus, after recrystallization from 96% ethanol, 11.45 g (yield | 72%) of 2-amino-4-trifluoromethyl-N- / 4-chloro-3 - (M-dimethylaminomethyl
     ideas) -sulfamoylbenzoyl / -phenylgide0
    five
    0
    five
    0
    zina with t. pl, nie).
    Calculated N
    33 199-200 С (with the following decomposition%: С 44.01, H 3.69;
    one
    15.10; ci 7.64.
    With „Hr ClF3NfOeS
    Found,%: C 43.98, H 3.62; N 11.98; C1 7.27.
    C) Repeat the procedure of Example 3 using 10 as the starting materials, g of the phenylhydrazine derivative prepared according to the procedure B of Example 28, 45 ml of pyridine and 3.6 g of potassium ethyl xanthate. Thus, 11.33 g (yield 100%) of 1- {4-chloro-3 - - (N-dimethylaminomethylidene) -sulfamoylbenzoyl-3-amino-5-trifluoromethylbenzimidazole-2-thion is obtained. This product is used without further purification.
    Example 29. The procedure of Example 14 was repeated using as starting materials 5.55 g of 1-amino-2-yenyl-5-trifluoromethylbenzimidazole, 15 ml of pyridine and 6.2 g of 4-chloro 3 (N-dimethylaminomethylidene) -sulfamoylbenzoyl chloride . B, the result is 9.7 g of 1- / -chloro-3 - (N-dimethylaminomethylidene) -sulfamylbenzoyl-amino-2-phenyl 5 trifluoromethylbenzimidazole, which is further hydrolyzed with 50 ml of 2N. sodium hydroxide solution solution as in Example 16. Thus, after recrystallization from butanol, 7 g (yield 98%) of 1- (4-chloro-3-sulphamoylbenzoyl) amino-2-phenyl-5 trifluoromethylbenzimidazole with t, square 282-28 C (with decomposition). The compound obtained contains 1 molecule of butol nola.
    Calculated,%: C 52.76; H 4.25; 9.8.
    Cr NmS1G3 Oe5
    Found,%: C 52.35; H A, 37,
    9.66.
    N
    N
    Getting the original products.
    A) Repeat the procedure of Example 14 using 66.5 g of 2-amino-4-β-trifluoromethyl-M-acetylphenylhydrazine, 70 ml of pyridine and 32.9 ml of benzoyl chloride as starting materials. As a result, after recrystallization from 96% ethanol, 90 g (yield 93.6%) of 2-benzoylamino-4-trifluoromethyl-M-acetylphenyl hydrazine are obtained, mp 212-214 ° C,
    Calculated,%: C 56.97. H 4.18, N 12.46.
    1736339
    34
    0
    s, "and m P3yog
    five
    0 n
    Found,%: C 57.15; H 4.08; N 12.48.
    B) After boiling 52.2 g of the phenylhydrazine derivative prepared according to method A of example 29 in 270 ml of glacial acetic acid for 6 hours, the resulting solution was evaporated under reduced pressure and the residue was triturated in water. The crystals are filtered off with vacuum, washed with water and dried at Ј0 ° C. As a result, after recrystallization from a 50% aqueous solution of ethanol, 46.3 g (yield 88.5%) of 1-acetylamino-2-phenyl 5 trifluoromethylbenzene are obtained. imidazole with m.p. 150-154 C,
    Calculated,%: C 60.19, H 3.79 13.16.
    CibHn..0
    Found: with 59.98; n 3.74; N 13.04.
    C) After boiling, 45 g of the benzimide – 5 dazole derivative obtained by the method B of Example 29 in a mixture of 100 ml of 96% ethanol with 300 ml
    2 n. The hydrochloric acid solution is clarified with active coal for 8 hours and filtered. After basifying the filtrate to a pH of 10 by adding a solution of sodium hydroxide, the precipitate is filtered off with vacuum, washed with water and dried at 80 ° C. As a result
    5 (after recrystallization from 96% ethanol get 34.1 g (yield 87%)
    1-amino-2-phenyl-5-trifluoromethylbenzimydazole with m.p. 200-203 C.
    Calculated,%: C 60.65, H 3.64. N 15.16.
    C / 4H, 0P3Mz
    Found,%: C 60.25, H 15.58.
    H, 24;
    45
    50
    55
    Example 30. The procedure of Example 14 was repeated, using as starting materials 9.88 g of 1-amino-2-methylthio-5-trifluoromethylbenzimidazole, 20 ml of pyridine and 12.2 g of 4-chloro-3- (N-dimethylaminomethylidene ) -sulfamoylbenzoyl chloride, Ta (yield
    dimethylaminomethylidene) sulfamoyl benzoyl T-amino-2-methylthiobenzimidazole, which is hydrolyzed using 100 ml of 2N. sodium hydroxide solution solution as in Example 16. After recrystallization from ethyl acetate,
     / JfJ Ыф WU iW l .Vf-- -f
    In this way, 19.4 g (98%) of 1- / 4-chloro-3 - (N-dimesh
    351
    15.45 g (yield 83) of 1- (4-chloro-3 -sulfamoylbenzoyl) amino-2 methylthio-5 trifluoromethylbenzimidazole with m.p. 126-128 C (with decomposition).
    Calculated, fc: C 41.34; H 2.73; N 10.34.
    C, 6H, GS1R3M ,, 038g
    Found,%: C 41.38; H 2.78; N 10.61.
    Getting the original products.
    A) After adding 69.96 g of 2-amino-4-trifluoromethyl-M-acetylphenylhydrazine to a solution of 19.07 g of potassium hydroxide in 300 ml of absolute ethanol in the mixture while stirring
    20.5 ml of carbon disulfide is added dropwise. The red solution that had formed was refluxed for 5 hours. The hot solution was clarified with activated charcoal and filtered. After adding 370 m of water and then 70 ml of a mixture of acetic acid and water in a ratio of 1: 2 to the filtrate, the crystalline precipitate is filtered with vacuum, washed with water and dried at 80 ° C. After recrystallization from a 50% aqueous solution of ethanol, 55.5 g (yield 67%) of 1-acetylamino-5 trifluoromethylbenzimidazole-2-thione with m. Pl. 294-295 ° C /
    Calculated,%: C 43.63J H 2.93) N 15.77.
    C / 0HSF3N3OS
    Found,%: C 43.52) H 2.95; N 15, Yu.
    B) 10 ml of dimethyl sulfate is added to a suspension containing 27.5 g of the benzimidazole derivative obtained by the procedure A of Example 30,
    in 200 ml of a normal solution of sodium hydroxide. At first, the suspension is difficult to mix, however, this phenomenon continues for only a few minutes. The mixture is stirred in a hot water bath for 30 minutes, then it is cooled. The precipitate was filtered with vacuum, washed with water and dried at 80dC. As a result, after recrystallization from benzene, 27.2 g (yield 94%) of 1-acetylamino-2-methylthio-5 trifluoromethylbenzimidazole with m.p. 175-178

    Calculated, -%: C 45.67, H 3.48; 14.52.
    C "H, oF3N3OS
    Found,%: C 45.36, H 3.76; 14.27.
    0
    five
    five
    0
    five
    0
    five
    0
    36
    C) 22.2 g of the benzimidazole derivative obtained by the method B of Example 30 is boiled in 80 ml of 2N hydrochloric acid for 6.5 hours and then evaporated to dryness under reduced pressure. The solid residue is dispersed in 80 ml of a normal solution of sodium carbonate and kept at an elevated temperature until bubbles precipitate. After cooling, the crystalline precipitate is filtered off with water and dried at the same time, after recrystallization from a 50% aqueous solution of ethanol, 16.88 g (88 , 5%) with 1-amino-2-methyl with 5-trifluoromethylbenzimide with vacuum, washed 80 C.
    ash with m. pl. 170-173 S.
    Calculated,%: C 43.72, H 3.26, N 16.99.
    C3IIsF3NjS
    Found% N 16.64.
    Take an example
    c 43.65; W, 17;
    31. 11.25 g of 1- (4-chloro-3-sulfamoylbenzoyl) -amino-5 trifluoromethylbenzimidazole-2-thione is repeated as a starting material, and 10.8 g (93% yield) are obtained as a result. (h-chloro-3-sulfamoylbenzoyl) -amino-2-methyl-thio 5 trifluoromethylbenzimidazole, which in all aspects is identical to the product obtained in Example 29. Example 32. After dropping 1.46 ml of embossed chloride in a solution containing 8.2 g 1- (4-chloro-3-sulfamoylbenzoyl) -amino-2-methyl-5-carboxybenzimidazole in 50 ml of methanol, while stirring the reaction mixture to n m reflux for 5 hours. The resulting clear solution was evaporated to dryness under reduced pressure and the solid residue was triturated with normal sodium bicarbonate solution. After decantation of the solution over the solid product, the residue is recrystallized from a mixture of dioxane and water in a 1: 1 ratio. Thus, 6.35 g (75% yield) of 1 (4-chloro-3-sulfamoylbenzoyl) -α-amino are obtained. -5g methoxycarbonylt2-methylbenzimidazole with m. Pl. 251-252 s (with decomposition ;,
    Calculated,%: C, 48.28; H, 3.58; J, N, 13.25; C1 8.39; S 7.58.
    C Hy-ClN Oj-S
    37
    Found,%: C 47.98, H 3.38, 12.95, Cl 8.12 | S 7.52. The proposed method receive
    the following compounds.
    1) 1- (4-Chloro-3-sulfamoyl-benzoyl) -amino-5-methoxycarbonyl-benzimidazole-2-thion, m.p. 252-26fC (with decomposition).
    Calculated,%: C 43.59; H
    N 12.7G, C1 8.04; s 14,55,
    2.97;
    C, 6H, 3C1N
    iox,
    5 ° g.
    Found,%: C 43.80; H 2.78, N 12.57: C1; 8.62; s 14.60.
    2) 1- (4-Chloro-31-sulphamoylbenzoyl) -amino-5 carboxybenzimidazol-2- -ion, mp, 290-295 ° С (with decomposition).
    3). 1- (4-Chloro-3-sulfamoylbenzoyl) -amino-5-carboxybenzimidazolone, m.p. 339 ° C.
    C 43.85; H 2.70;
    Calculated%
    N 13, s 7.80.
    C / 5H CIN406S
    Found,%: C 43.57; H 2.86; N 13.58; s 7.42.
    4) 1- (4-Chloro-3-sulfamoylbenzoyl) amino-5-methoxycarbonyl-2-methylthiobenzimidazole, mp, 186-188 C.
    Calculated,%: C, 44.88; H 3.32, v N 12.32; Cl 7.79; S 14,10.
    GO HIS C1N405SЈ
    Found,%: C 44.75i H 3.68; N 12.50; Cl 7.60; S 13.91.
    5) 1- (4-Chloro-3-sulfamoylbenzoyl) amino-5-carboxy-2-methylthiobenzimidazole, mp, 214-222 ° C (with decomposition).
    I
    Calculated,%: C 41, On; H 3.44} N 11.97; C1 7.57; S 13.07. C (6H, 3ClN Os-S24.5H2.0 Found,: C 41, OJ H 3.35;
    N 11.71; ci 7.11; s 13.15.
    6) 2-Benzylthio-1- (4-chloro-3 -sul-famoylbenzoyl) -amino-5-methoxycarbonylbenzimidazole, m.p. 111-118 C (with decomposition).
    Calculated,%: C 52.02, H 3.6G, N 10.55, C 6.68, S 12.08. CwHttClN Sa,
    Found, g: C 52,32; H 4.00; N 9.90 ;, C1 6.00; S 12.00.,
    7) 2-Benzylthio-1- (4-chloro-3 - -sulfamoyl) amino-5 carboxybenzimi dazol, t. Pl. 190-196 C (with decomposition).
    Calculated,%: C 51 LO; H 3, SG, N 10.84, C1 6.86; S 12.40. C23HjgClN405S2
    1736339
    38
    five
    five
    0
    five
    0
    five
    Found: C 49.23 J H 3.77, N p, oo; q 6.84; s n, 4o.
    8) 1- (4-Chloro-3-sulfamoyl) -amino-5 methoxycarbonyl-2-methylsulfonylbenzimidazole, m.p. 254-255 С
    (with decomposition).
    Calculated: C 41.93; H 3.10;
    N 11.50; ci 7.28; s 13.17.
    C, H Found,%: C 42.01; H 3.15; N 11.34; C1 7.35; S 1,3,01. | f
    9) 5 Carboxy-1- (4-chloro-3-sulfamoyl) -amino-2-methyl-sulfonyl 5 benzimidazole, so pl. 222-225 ° С (with decomposition).
    Calculated,%: C 40.64; H 2.77; N 11.85 / ci 7.50; S 13.56,
    C, 6HЈ3C1N40 S
    Found,%: C. 40.07, H 3.01; N 12.02; C.1,7,65; S 13.29.
    10) 1- / 4-chloro-3- (N-dimethylamino-methylidene) -sulfamoylbenzoyl / -amino-5 methoxycarbonyl-2-benzimidazole, m.p. 260-2СЗ С (with decomposition).
    11) 1- (4-Chloro-3 -sulfamoylbenzoyl) -amino-5 Cyanobenzimidazole-2- -thion, t. Pl. 315 C.
    Calculated,%: C 44.16; H 2, 0 N 17.17; Cl 8.69, S 15.72. C HjoClN Oj
    Found,%: C 44.40, H 2.67, N 16.94; ci 8.96; S 15.33.
    12) 5 Benzoyl-1- (4-chloro-3 - -sulfamoylbenzoyl) -amino-benzimidazol-2-thion, so pl. 233 ° C (with decomposition),
    Calculated,%: C 51.79, H 3.11 | N 11.5G, C1 7.28; s 13.17.
    C2iHlsClK406S2
    Found,%: C, 51.30; H 3.74, N 11.39; C1 7.40; s 13.50.
    13) 1 - (41-Chloro-3-sulfamoylbenzoyl) -amino-5-sulfamoylbenzimidazol-2-thione, m.p. 32b ° C (with decomposition).
    Calculated,%: C 36.40; H 2.62; N 15.16; C1 7.68; S 20.82. C HjiClN OjSj. Found,% t C 36.31; H 2.45,
    N 15.66; ci 7.36; 8d20,8o ...
    14) 1- (4-Chloro-3-sulfamoylbenzoyl) -amino-5-methylsulfonylbenzimidazol-2-thion, mp, 298-ZOO C.
    Calculated,%; C 39, H 2.82) N 12.16, C1 7.69; S 20.87.
    C, SH, 3 C1N405S3
    Found,% C 38.90; H 2.70; N 12.12; C1 7.98; S 20.60.
    391
    15) 1- (4-Chloro-3-sulphamoylbenzoyl) -amino-5 trifluoromethylbenzimidazole-2-tione, so pl. 282-283 C (with decomposition).
    Calculated,%: C 39.36; H 2.24; N 12.43J ci 7.86.
    CwH "F3ClN403Sa
    Found,%: C 39.09, H 2.12; N 12.20, C1 7.11.
    16) 1- (4-Chloro-3 -sulfamoylbenzoyl) -imino-2-methylthio-5 trifluoromethyl-benzimidazole.
    17) 1 - (4-Chloro-3-sulfamoyl benzoyl yl) -amino-5 methoxycarbonyl-2-me-0 tilbenzimidazole with m. Pl. 251-252 C (with decomposition).
    Calculated,% C 48.28 / H 3.58 |
    N 13.25; ci e.ze; s 7.58.
    d, K15
    Found: C, 47.98; H 3.38; N 12.95, C1 8.12; S 7.52.
    Example 33. A) 44.5 g of 1- (4-chloro-3-sulfamoyl-benzoyl) amino-5 carboxybenzimidazol-2-thione monohydrate with stirring are added in small portions in 200 ml of 1N. sodium hydroxide solution. After vigorous foaming decreases



    bath until a clear solution is obtained. The solution is evaporated in a water bath under reduced pressure to dryness. 44.4 g of white sodium salt of 1- (4-chloro-3-sulfamoyl benzoyl) -amino-5-carboxy-benzimidazole-2-thione are obtained.
    thirty
    Calculated% i Na 5,12.
    Cf5H “ClN O S2Na.
    Found,%: Na 5.15.
    The sodium salt thus obtained is dissolved in water, forming a clear solution with a pH of 7.,
    B) 44.5 g of 1- (4-chloro-3-sulfamoyl-benzoyl) -amino 5 carboxibibenimidazole-2-thione monohydrate with stirring are added in small portions to 200 ml of a solution of 6.9 g of potassium carbonate in distilled water. After vigorous foaming has decreased, the mixture is heated in a water bath until a clear solution is obtained. The solution is evaporated in a water bath under reduced pressure to dryness. 46.3 g of (99.5) potassium salt of 1- (4-chloro-3 -sulfamoylbenzoyl) -amino-5-carboxybenzimidazole-2-thione are obtained in the form of a white powder.
    9
    40 K 8.41

    Calculated
    C H ClN OfSaK
    Found,%: K 8.25.
    The potassium salt thus obtained is dissolved in water, forming a clear solution with a pH of 7.
    Following Example A and starting from a suitable carboxylic acid derivative, the following sodium salts are obtained. f f
    1- (4-Chloro-3 -sulfamoylbenzoyl) - amino 5 methylthiobenzimidazole sodium salt.
    Calculated,%: Na 4.97.
    C, t H, Ј
    Found,%: Na 4.85.
    1- (4-Chloro-3 -sulfamoylbenzoyl) -amino-5 carboxy-2-benzylthiobenzimidazole sodium salt. Calculated,% - Na 4,27,
    C H-r ClN Og-Si
    Found,%: Na 4.40.
    1- (4-Chloro-3-sulfamoylbenzoyl) -amino-5 carboxy-2-methylbenzimidazole sodium salt.
    Calculated,%: Na 5,3.
     H, g ClN405Na
    Found,%: Na 5.30.
    1 - (4-Chloro-3 -sulfamoylbenzoyl) -amino-5-carboxybenzimidazole sodium salt. . °
    Calculated,%: Na 5.39.
    CffHf0ClN4C 5SNa
    Found,%: N 5.45.
    Following Example B and starting from a suitable carboxylic acid derivative, the following potassium salts are obtained. ;
    1- (4-Chloro-3 -sulfamoylbenzoyl) -amino-5 carboxy-2-methylthiobenzimidazole potassium salt
    Calculated,%: K 8,16,
    С / б Н «С1 055гК
    Haf-deno,%: K, 8.01.
    1- (4-Chloro-3 -sulfamoylbenzoyl) -amino-5 carboxy-2-benzylthiobenzimidazole potassium salt.
    Calculated% C 7.04.
    Ci2H ClN405S8K
    Found,%: K 7, T1,
    1 - (4-Chloro-3-sulfamoylbenzoyl) -Ino-5-carboxy-2-methylbenzimidazocarium salt.
    Calculated, Ј: to 8.75. Found,%: K 8.60. 1- (4-Chloro-3 -sulfamoylbenzoyl) -amino-5 carboxybenzimidaeol potassium salt,
    Calculated,%: K 9.03.
     C1N405SK
    Found,%. K 8.95.
    The biological effect of salts corresponds to the action of adequate acids.
    Study of the salidiuretic effect on rats.
    The classification tests were carried out on female LATI CFY rats with an average live weight of 240 g. The animals were kept on standard rat food and were not allowed to eat for 16 hours before the experiment, but they were not limited in water. To evaluate the diuretic effect, I use the Lipschitz method, modified by Kawava and Kahn.
    The effect of a single oral dose of the proposed compounds on the diuresis of water, sodium and potassium for 2 ° C as a percentage of the results of simultaneous measurements in control animals, as well as the effect on the ratio between sodium and potassium in the excreted urine is shown in Table. one.
    Investigation of the salidiuretic effect on dogs.
    The compound described in Example 1 was tested on perineotomized female dogs. The dogs are preliminarily observed for 2 weeks without any treatment, and then tix is subjected to surgical treatment. To adapt, starting from the fourth week after surgery, the animals' bladder is released with a catheter or treated with saline with a stomach probe. During the experiment, dogs are kept on a standard diet, giving them an unlimited amount of water. Dogs are not given food on experimental days, they receive only 20 ml / kg of water. 7.7 mmol / kg of sodium and 6.02 mmol / kg of potassium are administered with food.
    On the day of the experiment, animal bladders are emptied and blood samples are taken from the leg vein, after which the diuretic solution or solvent is administered to the animals using a gastric probe at a dosage of 10 ml / kg (control group). Animals are placed individually on
    o
    five
    0
    five
    0
    five
    0
    five
    0
    five
    cells for metabolic studies. After 7 and 2k hours, respectively, catheters are inserted into the bladders of the animals and urine is collected by washing the cells for metabolism studies. After 2k hours after insertion of the catheter, blood samples are taken again.
    In addition to the volume recovered, the content of sodium and potassium ions in the urine, as well as the content of glucose and cholesterol in serum, are determined.
    Radiation of antihypertensive effect on rats.
    These studies were performed on Okamoto female rats (SH) with spontaneously developing hypertension. At least one week before the start of the experiment, the animals are seated in cages and kept in water and semi-synthetic food for rats, which are given to them without restriction. At the same time, blood pressure is measured daily for each animal and gastric probes are administered to the immobilized animals. Animals whose blood pressure is less than 170 mm Hg are excluded from the experiment. Art. Based on the results of daily measured blood pressure, animals are divided into experimental groups, in all individuals whose mean blood pressure and deviations are approximately equal;
    At the beginning of the experiment, animals are given, respectively, 0.2 ml / 100 g of a solution containing the test compound, and 1 ml / 100 g of a furosemide solution. In each experiment, animal groups are also examined, which are given a physiological solution and a solvent, respectively.
    Before measuring blood pressure, animals are placed in a light- and soundproof chamber, and then immobilized. At the root of the tail, an inflatable rubber cuff (in each case at the same place) is fixed, which is connected to a pressure gauge.
    The material and diameter of the cuff for the tail are standardized. The measurement is carried out in accordance with the Riva-Rocci principle. The method of pulsations is used to measure systolic blood pressure. The heart rate is measured using a piezoelectric crystal, placed
    where K is hydrogen, C-C-alkyl, C 1 -alkylthio, phenyl, mercapto, RJL is hydrogen,
    where Rz have the specified value, X is chlorine,
    R 5 and R4 - hydrogen or together form the group SSh (SNe) g and a protective group,
    removed in alkaline medium and target
    the product is isolated in free form
    or in the form of salt.
    Table 1
    Compiled by G.Zhukova edaktor N.Gunko Tehred A.Kravchuk
    Order 1825
    Circulation
    VNIIPI State Committee for Inventions and Discoveries at the State Committee on Science and Technology of the USSR 113035, Moscow, Zh-35, Raushsk nab. 4/5
    at". ". pl 1zhag izh il mr n Mr -LI U Tifchsh PL-I I.
    Production and publishing plant Patent, Uzhgorod, st. Gagarin, 101
    table 2
    Proofreader S. Shekmar
    Subscription
    权利要求:
    Claims (1)
    [1]
    Claim
    The method of obtaining 4-chloro-3-sulfamoylbenzoic acid of the general formula I:
    where and R ^ have the indicated meanings, they are reacted with a carboxylic acid derivative of the general formula III where R * is hydrogen, -``C ^ -alkyl, C 4 -Cd-alkylthio group, phenyl group, mercapto group, 'Rjl - hydrogen, where R 2 have the indicated value,
    X is chlorine
    R y and R 4 • - hydrogen or together form a group = CHO (CHD) g and a protective group, are removed in an alkaline medium and the target product is isolated in free form or in the form of a salt.
    Table 1
    Compound Example Water Sodium Potassium Sodium / Potassium Ratio 1 2 3 4 . 5 Control experiment 100 100 100 s oh 1 148 152 122 4.6 7 129 133 110 3,7 9 99 105 95 3.4 16 111 117 109 3.3 19 117 121 120 3,1 22 107 99 103 3.7. 23 98 105 102 m 24 108 104 104 3.9 26 107 108 106 4.0 27 95 94 85 4.3
    2 3 4
    29th 97 101 105 2.9 thirty 114 106 108 3.0 32 117 121 115 3.2 Hypothiazide 124 129 114 3,5 Furosemide 107 106 105 2.7
    'ι
    table 2
    Compound Blood pressure its dosage prior to drug administration; mm
    Lowering blood pressure, over time, h
    6 12 24
    Thinner 195
    Furosemide
    100 mg / kg 201 5.1 25.3 39 19,4 3 1,5 The compound of example 1 5 mg / kg 216 31 14.3 45 20.1 thirty 13.8
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    DE10132896A1|2001-07-06|2003-01-16|Bayer Cropscience Ag|Heterocyclic amide derivatives|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    HU876131A|HU207051B|1987-12-30|1987-12-30|Process for producing 4-chloro-3-sulfamoylbenzoic acid hydrazides and pharmaceutical compositions comprising such compounds|
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